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Malignant Hyperthermia Malignant hyperthermia (MH) is a rare (incidence of 1 in 50,000–70,000 in the UK), autosomal dominant condition, affecting males (62%) more than females (38%) and may occur after many previous anaesthetics. Mechanism The exact mechanism has not been fully elucidated but the ryanodine receptor located on the membrane of the sarcoplasmic reticulum and encoded on chromosome 19 is intimately involved.
Subscribe to our YouTube Channel What do anesthesia, technology, and…peacocks have in common? We’re convinced that the only way to know is to interview Tom Wilson, VP of sales for Graphium Health – an anesthesia solutions company. Join Tom and us as we discuss his career, the changes he’s seen in the healthcare and anesthesia landscapes over the last 9 years.
Milrinone, an analogue of amrinone, is a bipyridine derivative with inotropic activity that is almost 20 times more potent than that of amrinone and a shorter half-life. Milrinone is an effective inodilator for patients with decompensated HF and low CO after cardiac surgical procedures. Suggested administration of milrinone is a loading dose of 50 μg/kg over 10 minutes, followed by an infusion of 0.5 μg/ kg per minute (0.375–0.75 μg/kg per min).
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